The letter is a response from Carl Albert to Sula Goodman, discussing various topics such as a visit from Hugh, feedback on articles, personal struggles with grant requests, job opportunities, and personal projects. Sula expresses frustration with the Public Health Service's rejection of her grant request and seeks advice from Hugh. She also discusses her struggles with her career and personal projects, such as a failed property investment. She expresses hope for a change and discusses potential job opportunities in other fields.